Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: A pathway analysis of genome-wide association studies

Grants

Funding Acknowledgements

This work was supported by the Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health and RO1CA154823. The International Agency for Research on Cancer/Central Europe study was supported by grant R03CA123546-02 from the NCI-NIH and grants from the Ministry of Health of the Czech Republic (NR 9029-4/2006, NR9422-3, NR9998-3, and MH CZ-DRO-MMCI 00209805). The work at Johns Hopkins University was supported by NCI grants P50CA062924, R01CA97075, R01CA154382, and U01CA247283. Additional support was provided by the Lustgarten Foundation, Susan Wojcicki and Dennis Troper, and the Sol Goldman Pancreas Cancer Research Center. The Mayo Clinic Biospecimen Resource for Pancreas Research study is supported by the Mayo Clinic SPORE in Pancreatic Cancer (P50 CA102701). The MD Anderson case-control study was supported by NIH-NCI grant R01CA098380. The Pancreatic Cancer Cohort II studywas partially supported by a supplemental grant to CA098380. The Multiethnic Cohort study was supported by NCI grant U01CA164973. The Memorial Sloan Kettering Cancer Center Pancreatic Tumor Registry is supported by P30CA008748, the Geoffrey Beene Foundation, the Arnold and Arlene Goldstein Family Foundation, and the Society of MSKCC. The PACIFIC study was supported by grant RO1CA102765 from the Kaiser Permanente and Group Health Cooperative. The Queensland Pancreatic Cancer Study was supported by grant 442302 from the National Health and Medical Research Council of Australia (NHMRC). REN is supported by a NHMRC Senior Research Fellowship (1060183). The University of California, San Francisco, pancreas study was supported by NIH-NCI grants R01CA1009767, R01CA109767-S1, and R0CA059706 and by the Joan Rombauer Pancreatic Cancer Fund. Collection of cancer incidence data was supported by the California Department of Public Health as part of the statewide cancer reporting program; the NCI's SEER Program under contract HSN261201000140C awarded to CPIC; and the CDC's National Program of Cancer Registries under agreement U58DP003862-01 awarded to the California Department of Public Health. The Yale pancreas cancer study is supported by NCI-NIH grant 5R01CA098870. The Connecticut Pancreas Cancer Study was approved by the State of Connecticut Department of Public Health Human Investigation Committee. Certain data used in that study were obtained from the Connecticut Tumor Registry in the Connecticut Department of Public Health. The authors assume full responsibility for analyses and interpretation of these data. Studies included in PANDoRA were partly funded by the Czech Science Foundation (P301/12/1734); the Internal Grant Agency of the Czech Ministry of Health (IGA NT 13 263); the Baden-Wurttemberg State Ministry of Research, Science and Arts (H. Brenner); the Heidelberger EPZ-Pancobank (M. W. Buchler and team: T. Hackert, N. A. Giese, Ch. Tjaden, E. Soyka, M. Meinhardt; Heidelberger Stiftung Chirurgie and BMBF grant 01GS08114); the BMBH (P. Schirmacher; BMBF grant 01EY1101); the "5 x 1000" voluntary contribution of the Italian Government; the Italian Ministry of Health (RC1203GA57, RC1303GA53, RC1303GA54, and RC1303GA50); the Italian Association for Research on Cancer (A. Scarpa; AIRC 12182); the Italian Ministry of Research (A. Scarpa; FIRB-RBAP10AHJB); the Italian FIMP-Ministry of Health (A. Scarpa; 12 CUP_J33G13000210001); and the National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, UK. The American Cancer Society funds the creation, maintenance, and updating of the Cancer Prevention Study II cohort. Cancer incidence data for CLUE were provided by the Maryland Cancer Registry, Center for Cancer Surveillance and Control, Department of Health and Mental Hygiene (http://phpa.dhmh.maryland.gov/cancer).The Melbourne Collaborative Cohort Study (MCCS) cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by Australian National Health and Medical Research Council grants 209057, 396414, and 1074383 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health andWelfare, including the National Death Index and the Australian Cancer Database. The New York University study (AZJ and AAA) was funded by NIH grants R01CA098661 and UM1CA182934 and center grants P30CA016087 and P30ES000260. The PANKRAS II study in Spain was supported by research grants from Instituto de Salud Carlos III-FEDER, Spain: Fondo de Investigaciones Sanitarias (FIS: PI13/00082 and PI15/01573) and Red Tematica de Investigacion Cooperativa en Cancer, Spain (RD12/0036/0050); and European Cooperation in Science and Technology (COST Action BM1204: EU_Pancreas), Ministerio de Ciencia y Tecnologia (CICYT SAF 2000-0097), Fondo de Investigacion Sanitaria (95/0017), Madrid, Spain; Generalitat de Catalunya (CIRIT -SGR); "Red tematica de investigacion cooperativa de centros en Cancer" (C03/10), "Red tematica de investigacion cooperativa de centros en Epidemiologia y salud publica" (C03/09), and CIBER de Epidemiologia (CIBERESP), Madrid, Spain. The Physicians' Health Study was supported by research grants CA097193, CA34944, CA40360, HL26490, and HL34595 from the NIH. The Women's Health Study was supported by research grants CA182913, CA047988, HL043851, HL080467, and HL099355 from the NIH. The Health Professionals Follow-up Study is supported by NIH grant UM1CA167552 from the NCI. The Nurses' Health Study is supported by NIH grants UM1 CA186107, P01CA87969, and R01CA49449 from the NCI. Additional support was provided from the Hale Center for Pancreatic Cancer Research, U01CA21017 from the NCI, the US Department of Defense (CA130288), Lustgarten Foundation, Pancreatic Cancer Action Network, Noble Effort Fund, Peter R. Leavitt Family Fund, Wexler Family Fund, and Promises for Purple to BMW. Fundings for EJ Duell included Instituto de Salud Carlos III, cofunded by FEDER funds-a way to build Europe-(FIS: PI15/00659 and PI18-00192); Fundacio La Marato de TV3 (20192-30-); Agency for Management of University and Research Grants (AGAUR) of the Catalan Government grant 2017SGR723; and the Spanish Association Against Cancer Scientific Foundation. The Shanghai Men's Health Study is supported by NIH grant UM1CA173640. The Shanghai Women's Health Study is supported by NIH grant UM1CA182910. The Women's Health Initiative (WHI) program is funded by the NationalHeart, Lung, and Blood Institute, NIH, US Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. The SELECT study is supported by NIH grant U10CA37429 (CDB) and UM1CA182883 (C. M. Tangen and IMT). This study utilized the high-performance computational capabilities of the Biowulf Linux cluster at the NIH (https://hpc.nih.gov/systems/). The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the NIH and by NCI; the National Human Genome Research Institute; the National Heart, Lung, and Blood Institute; the National Institute on Drug Abuse; the National Institute of Mental Health; and the National Institute of Neurological Disorders and Stroke. The data used for the analyses described in this article were obtained from the tissue data from the GTEx Portal on June 2019 and July 2020.